The commercial activity of this urban complex (Tirunelveli) serves the needs of the major part of the district. At present, the major industrial developments are the cement factory, chemical carbide, modern rice mill and four cotton mills situated along Madurai road and in Pettai. There is no appreciable developments within the town, except some agro industries, service industries including automobile repairs and the small scale industrial units at Pettai.
Industrial Units are springing up in the Industrial Estate, located at Pettai. The 'TANSI' is located within the premises of the Industrial Estate. Automobile and other service industries are located very densely along the Nellaiyappar High road in Tirunelveli town. Cottage industries are also predominant in Tirunelveli. Beedi making, Mat weaving are the major cottage industries. Tannery industries in small scale are also found in this town. In addition to these industries, a few small scale units of brick kilns and oil mills exist in the industrial area of this town.
| S.No | Company | Address | Industry |
| 1 | Arasan & Co | High Road, Tirunelveli 627001. | Caltex Agencies |
| 2. | Annamalai Industries | High Road, Tirunelveli 627 001 | Pump Works |
| 3. | Annamalaiyar Bricks | 170, High Road, Tirunelveli 627 001 | Bricks |
| 4. | Arasan Beedi Company | Melapalayam , Tirunelveli | Beedi Manufacturers |
| 5. | Arun paper Industries | Mavadim Manoor Panchayat Union, Tirunelveli Dt | Manufacturer Of M.G papers |
| 6. | Agri Carb (P) Ltd | A-4, Jawagar Nagar , "A" Colony , Tirunelveli 627 007 | Mfg Of Briquettes |
| 7. | Aravind Spinners | 41-A, Cheran Mahadevi Road Tirunelveli-627 006 | Yarn Merchants |
| 8. | Apollo Saline Pharmaceuticals (P) Ltd | 5-C, Trivandrurm Road Tirunelveli 627 003 | Manufacturer Of I.V. Fluids & Injection |
| 9. | Bharat Motors | Industrial Estate , Pettai , Tirunelveli 627 010 | Mattress |
10. | The Bell Produts Co | Tiruchendur Road Palayamkottai-627 002 E-mail: postmaster@lilycomp.com URL: www.bellpins.com | Pins Manufacturers |
| 11. | Coats Viyella Ltd | Vikramasinga Puram Tirunelveli Dt | Spinning & Weaving |
| 12. | Dharani Sugars Ltd | Vasudeva Nallur Tirunelveli Dt | Sugars |
| 13. | Flexi Back | 9, Ponmani Colony Maharaja Nagar Tirunelveli 627 011 | Manufacturer Of Poly Bags |
| 14. | Ganapathy Mills Ltd | Sangar Nagar Tirunelveli 627 007 | Spinning Mill |
| 15. | Glope Radio & Co | Cheran Mahadevi Road, Pettai Tirunelveli 627 001 | Radio Service |
| 16. | Gomathi Mills (P) Ltd | Viravanallur Tirunelveli Dt 627 426 | Spinning Mill |
| 17. | Godrej Agrovet (P) Ltd | Seevalaperi Road Palayamkottai Tirunelveli 627 002 | Cattle Feed Manufacturers |
| 18. | Gitanjali Mills Ltd | Sankaran Kovil Tirunelveli Dt | Spinning mill |
| 19. | Gandhiji Nature Cure Hospital | Pettai , Tirunelveli 627 004 | Mfg Herbal Products |
| 20. | India Cements Co Ltd | Sangar Nagar , Tirunelveli 627 357 | Cement |
| 21. | Kadiraven Chemicals (P) Ltd | Ambasamudram Road, Munnerpallam Tirunelveli 627 356 | Mfg Of Calcium Carbide |
| 22. | Kasiyantha Cooking Ranges (P) Ltd | Industrial Estate Pettai , Tirunelveli 627 010 | Pressure Cookers |
| 23. | Kovilpatti Lakshmi Flour Mills Ltd | Gangai kondan Tirunelveli-627 352 | Flour Mills |
| 24. | Kumar Spinng Mills (P) Ltd | V.M . Chatram Tirunelveli | Spinning Mill |
| 25. | Kali Aerated water Works (P) Ltd | 127, Trivandrum Road, Trinelveli 627 002 | Aerated water |
| 26. | Karpagam Spinners (P) Ltd | A-11, Veerabagu Nagar, Pettai Tirunelveli 627 004 | Spinning Mill |
| 27. | Krishna Mines | 23, Sripuram Tirunelveli 627 001 | Lime Stones |
| 28. | MKM Chamber Bricks | 49-B, Kailasapuram North St Tirunelveli | Bricks Manufacturers |
| 29. | Muthaiah Brothers | Industrial Estate, Pettai Tirunelveli 627 010 | Industries Machinery |
| 30. | K.Mahadevan Poly Bags | 32/33, A.P. Mada Street Tirunelveli | Manufacturers of Polythene Bags |
| 31. | Rajavally Company | High Road, Tirunelveli 627 001 | Beedi Leaves |
| 32. | Ragavendra Spinners (P) Ltd | A/9, Veerabagu Nagar, Tirunelveli 627 001 | Spinning Mill |
| 33. | Penguin Paper Industries | Pettai Tirunelveli | Paper Products |
| 34. | Seyadu Beedi Company | Sindupoondurai, Tirunelveli 627 001 | Beedi |
| 35. | Sundaram Industries ltd | Trivandrum Road, Tirunelveli. 627 001 | Tyre Retraders |
| 36. | Sultan Pillai & Sons | High Road Tirunelveli 627 001 | Beedi Manufacturers |
| 37. | Sun Paper Mills Ltd | Cheran Mahadevi Tirunelveli Dt 627 414 | Paper Mills |
| 38. | N.Sangaranarayanan & Sons | 121, Satyamurthi St Tirunelveli 627 006 | Brass Vessels Manufacturers |
| 39. | Seyad Cotton Mills (P) Ltd | 4G, salai Street, Sindupoondurai Tirunelveli 627 001 | Spinning Mill |
| 40. | Seyad Cottage Industries | 7-C, Maharaja Nagar Tirunelveli 627 011 | Beedi Manufacturers |
| 41. | Sri Kailas Packagings | 29, Industrial estate Pettai , Tirunelveli 627 010 | Manufacurer Of Cartons |
| 42. | Sri Ragavendra paper Products | 49- M, Kailasapuram North St Tirunelveli 627 001 | Manufacturer Of Paper Products |
| 43. | Sri Balaji papers | 32-B, New Colony Vannarpet , Tirunelveli | Manufacturers of Boards |
| 44. | T.V.S.& Sons Ltd | 4/178, Trivandrum Road, Tirunelveli. 627 001 | Motor Car Sales |
| 45. | T.P.S. Ramsait Beedi Factory (P) Ltd | High Road Tirunelveli 627 001 | Beedi |
| 46. | Thirumalai Mills | 112 East Car St Tirunelveli 627 006 | Spinning Mill |
| 47. | Tri Star Hortitech (P) Ltd | 23, Sripuram Tirunelveli | Mfg Of Dried Flowers |